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Thyroid problem, insufficient progesterone

Question

I am 38 yrs old & have had 3 miscarriages over the past 5 years. In all 3 cases my progesterone levels were insufficient to sustain the pregnancies, & I miscarried usually in my 6th wk.  Tests revealed a mildly low thyroid, and a fibroid (said to be located in an area which should not be a cause of miscarriage or infertility). These tests were done just over 2 yrs ago, and I am now in my 7th wk of pregnancy. My thyroid problem has been regulated with a low dose of synthroid for the past 2+ yrs. I am again testing low (was at 11 in wk 6, now at 13 in wk 7). My doc put me on Crinone 8% twice a day.  The increase from 11 to 13 was over 4 days, all taking the Crinone. He is not optimistic but instructs me to continue. Do I have ANY chance of making it through and taking this to term??

Answer

Last Updated: July 3, 2013
These progesterone levels are much too low. The absorption and dose of Crinone 8% is inadequate. This pregnant mother needs to add or substitute her progesterone supplementation with progesterone in oil which usually comes in either 50mg/ml or 100mg/ml given as an intramuscular injection. I would recommend a minimum of 200mg given IM twice a week. This needs to be given under the direction of a physician who is willing and educated in giving progesterone supplementation in this manner. This will help maximize the chance of this patient carrying her unborn child to term.

Nicholas Jauregui MD

Answered By:

Nicholas Jauregui MD

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