Low Estradiol on Day Three of Cycle

Question

I am 26. I have had four miscarriages. Recently I had cycle day three labs done. The results are as follows:
FSH 5.5
TSH 1.33
Prolactin 6.5
Estradiol less than .1

How is it possible for a person of my age with normal FSH, TSH, and prolactin to have virtually NO estradiol? Most of the stuff I find online say that levels less than 20 are getting to be “too” low and can cause symptoms. What about having none? Women post menopause and even men have higher levels than I do. I am waiting for an appointment with a reproductive endocrinologist but until then I’m going crazy! I’m not asking for a diagnosis, there are obviously other tests that are going to need to be run, but is there any sort of guidance you can give me?

Amanda

Answer

Last Updated: September 1, 2022
Dear Amanda,

Estradiol fluctuates throughout the cycle. It is appropriate for it to be at a very low level at day three of the cycle. If it is too high, it signifies that the follicle may be maturing too early, which can happen if a woman is pre-menopausal.

M. Davenport, MD

Answered By:

Mary Davenport, MD, MS
Mary Davenport, MD, FACOG, an obstetrician/gynecologist from the Oakland Region of California, offers telehealth services over MyCatholicDoctor.com She graduated from Tufts University School of Medicine and completed her residency at UC San Diego. Dr. Davenport is a Fellow of the American College of Obstetrics and Gynecology, and serves on the Advisory Board of the California Association of Natural Family Planning.

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