High Risk Pregnancy


I am 22 yrs. old and three months pregnant. I have Neurofibromatosis type 1 and have two brain gliomas in the basal ganglia. My OB prescribed Prometrium 200 mg. twice a day. Hormones aggravate NF (neurofibromatosis) and I am concerned if my baby has NF (it’s genetic) that the Prometrium will make it worse.
Also I have been experiencing severe headaches and confusion and I am concerned that the brain gliomas are growing because of the Prometrium. My OB is not concerned and says he does not know much about NF but that I should take the Prometrium because my progestrone level is low.

Can you give me advice?



Last Updated: January 18, 2022
Dear Wendy,

You are correct in being concerned about the impact of your pregnancy and hormones on your neurofibromatosis and gliomas. This is a difficult and complex medical condition. In reviewing the literature, it appears that hormonal stimulation sometimes can affect your tumors, but sometimes does not. You are in a high risk pregnancy situation, and should consult with a high risk pregnancy physician (perinatologist) as soon as possible. Perinatologists are used to dealing with women with serious medical conditions during pregnancy. In addition, you may need consultation with neurologists, imaging specialists and oncologists to ascertain whether or not your gliomas are growing. A perinatologist could guide you through this process.

Hormone levels during pregnancy are high and increase markedly through all three trimesters. The additional progesterone in Prometrium may or may not significantly affect the progesterone level you have just by virtue of being pregnant. You do not state why you are on Prometrium or if any progesterone levels were obtained before putting you on Prometrium. In any medical condition you always try to determine if the benefits of a treatment outweigh the risk. In your case, you would need to take into account the risk of miscarriage or premature labor, your progesterone levels, and whether or not your gliomas are sensitive to progesterone.

Since you state that your doctor is not very familiar with neurofibromatosis, you need the advice of another physician who truly understands your disease in the context of your pregnancy. You may need to go to a university hospital or large medical center to find someone with the expertise to help you. It is possible that a perinatologist could assist you and your current obstetrician, but it is also possible you may be better off under the care of a high risk specialist for the remainder of your pregnancy and delivery.

Best wishes in getting really good care, and a safe pregnancy and delivery.

Mary L. Davenport, M.D.

Answered By:

Mary Davenport, MD, MS
Mary Davenport, MD, FACOG, an obstetrician/gynecologist from the Oakland Region of California, offers telehealth services over MyCatholicDoctor.com She graduated from Tufts University School of Medicine and completed her residency at UC San Diego. Dr. Davenport is a Fellow of the American College of Obstetrics and Gynecology, and serves on the Advisory Board of the California Association of Natural Family Planning.

Read more related questions

Is Progesterone Supplementation Moral?

I am currently 28 weeks pregnant with my second child. My first was born premature. My ob suggested progesterone injections starting at 16 weeks through…

Stressed I Might Be Pregnant

I am really stressed. I just got out of a four year relationship and I am worried I might become pregnant. No symptoms but it…

Are Fibroids Causing Bleeding During Pregnancy?

Hello, I am 45 years old and have large fibroids. I was about to have surgery to remove the womb. I am now seven weeks…

Scared I Am Miscarrying

I am writing because I am 13 weeks pregnant by ultrasound and LMP (but 11 weeks by my chart). This is my 4th pregnancy, I…

Scared Progesterone Can Harm My Baby

I am 32 years old and this is my first pregnancy. I have never had a miscarriage but when I started bleeding (hematoma) at 12…

Should I Stop Nursing Since Pregnant

I am four weeks pregnant with my third pregnancy and still nursing my nine month old pretty frequently. I am 30. I nursed during my…

Progesterone in Pregnancy—History of Miscarriage and Pre-Term Delivery

We are seven weeks pregnant after trying for over a year. We miscarried last year after being on Prometrium for low progesterone and infertilty (infertile…

Desperate for Explanation of Brown Spotting

I had sexual intercourse with my boyfriend and I am currently age 22. I finished my period on March 10th and the last time I…

Is My Progesterone Too Low for 15 Weeks Pregnant?

I am 42 years old and 16 weeks pregnant. I have had four first trimester losses (before nine weeks). I am MTHFR compound hetero (C677…

Estimating Date of Conception

How can my fertility doctor be sure I conceived on May 14? My period started on April 30. My six week five day ultrasound showed…

Could I Be Pregnant Without Intercourse?

I am 18, and my period has not yet become regular, but it has been over two months since my last period, which was June…

Did I Conceive May 11th or May 12th?

I was reading thru questions asking about “Who is the father?” One of the questions asked seemed very similiar to the situation that I’m going…

Create An Account

This is not a membership, this is an account for our CANFP website. If you decide you would like to sign up for one of our memberships later, you can do so with or without this account.

First Name *
Last Name *
E-mail *
Username *
Password *
Confirm Password *
Edit Profile
Order History
Shipping and Billing
Login Information
Notification Settings
Notification Subscriptions

CANFP conducts varied outreach programs to the community at large, in addition to serving our members (NFP users, teachers, and advocates).

CANFP provides education programs tailored to the audience, not only on Natural Family Planning, but on the wide variety of topics related to it.

Programs can be continuing education for NFP Professionals, introductory information for a lay audience of youth or adults new to the topic, or specifically tailored to the interests of a professional audience, such as educators, physicians, or clergy. Content is faith based or secular, whichever is suitable for situation.

CANFP offers a variety of resources for those just discovering Natural Family Planning, as well as to meet the varied needs of our CANFP Members. Most resources are available to any visitors to our site. Some resources do ask you to register as a site user in order to access them, others are available only to CANFP Members.

CANFP statewide conferences, regional events offered in collaboration with local partners, events featuring CANFP speakers, or exhbit, as well as other events throughout the state of interest to our NFP community.  Come meet one of our experts at one of these events or book a speaker for your own upcoming event.

CANFP depends on the gifts, talents, and generosity of our members and supporters. The success of our mission depends on the collaboration of our members. Please consider contributing your time treasure and talent through CANFP to share the good news of NFP with the world! Both volunteer and contracted positions available.

Stay informed by joining our email list

* indicates required
Which role(s) best describes you?